Sentence examples for drastic modification in from inspiring English sources

The acute distinction between the stages makes the staging unrealistic since the drastic modification in treatment based on a change of stage may be based on a slight shift around the stage boundary.

Recently, in a meta-analysis of the published data concerning HER2 status stability among primaries and metastases, Carlsson et al (2004) confirmed that there was no drastic modification in HER2 status between primary tumours and their locoregional lymph node metastases and their distant visceral metastases.

These drastic modifications in appearance and physiology require massive histolysis and histogenesis.

Therefore, genes belonging to essential ancient gene networks, which optimized their roles early in evolution, are expected to present high conserved components across a species tree as well as few drastic modifications in the course of their evolution.

Since the head undergoes drastic modifications in a few hours of growth, we registered the time-lapse reconstructions onto a reference system based on the fish anatomy; the positions of the eyes were automatically detected at each time point (supplementary material Methods) and used as landmarks (supplementary material Fig. S6 and Movie 6).

Behavioral theory also suggests that small changes (i.e. gradual shaping of new behaviors with small incremental changes toward a goal) should be easier to initiate and maintain than larger behavior changes since they represent less drastic modifications in behavior [ 17].

Two cellulose synthase genes were over-expressed in bm3 or AS225 internodes whereas no drastic modification was described in cellulose content in bm3 plants.

This is particular significant as several recent studies indicate that perturbation of cilia formation or function observed in several genetic diseases results in drastic modification of the cell cycle [38].

However, in some cases such drastic modifications result in deteriorated strain performances, as the resulting flux distribution of such an intervention might not be optimal anymore, due to the interplay of the metabolic pathways in the producer strain.

It is demonstrated that, as the corner shape is slightly changed, the aerodynamic characteristics result in drastic modification.

The combination of artemisinin and 3CA resulted in a drastic modification of artemisinin's activity (Table 3).