Sentence examples for drastic impairment from inspiring English sources

These data provide the first evidence that cadmium interacts with ribosomal genes and results in a drastic impairment of the functional activity of the nucleolus, an essential organelle for cellular survival.

In contrast, Endo180 shRNA cells showed a drastic impairment in their ability to invade through a fibrillar collagen I matrix (p = 0.0099) (Figure 6C).

Indeed, ablation of protocadherin α and γ subclusters in mice causes defects in axonal projection of olfactory sensory neurons to the olfactory bulb [12] or drastic impairment in synaptic formation and extensive loss of interneurons in the spinal cord [5], [13].

Therefore, it is possible that the drastic impairment of fracture repair is a consequence of the disruption of multiple CCR2-dependent processes.

We suggest that a regulatory rather than a metabolic defect is responsible for the drastic impairment of brain function in ZS patients.

These mice displayed a drastic impairment in postnatal muscle growth, with reorganisation of the mitochondrial network and reduction of mtDNA quantity, without the deficiency of mitochondrial bioenergetics.

This indicates that growth of DILP6 mutants is compromised relative to control animals upon starvation, and therefore that the increase in DILP6 expression observed upon starvation protects larvae from drastic impairments of organismal growth.

Additionally, B cell and T cell development are also extensively affected by APEC infection in challenged-susceptible birds, resulting in drastic host impairment in early response to infection.

RP is a leading cause of blindness resulting in incurable visual impairment and drastic reduction in the Quality of life of the patients.

Alzheimer's disease (AD) is an age-associated neurodegenerative disorder that causes severe impairment of cognitive function leading to a drastic decline in the quality of life.

Identification of domestication genes in crops revealed that most of the drastic changes during domestication are the result of functional impairments in transcription factor genes, and creation of new functions is rare.