Suggestions(1)
Exact(2)
Altogether, 21 protein candidates were identified with the most drastic fold change exhibited by APOA-1 and MXRA8.
Twenty one proteins were identified as discriminating species among which apolipoprotein A-1 and Matrix-remodeling protein 8 had the most drastic fold changes being over- and underrepresented, respectively, in steroid sensitive compared to steroid resistant urine samples.
Similar(58)
A drastic 3.5 fold reduction in the oxidation rate exhibited by the truncated Mtb BfrB in comparison to the native protein along with the crystallographic observations stated above imply the role of this C-terminal region in facilitating the iron entry from the three-fold channel towards the ferroxidase centre.
Similar enhancement was observed in other instances of confined guidance (e.g., microfluidic channels), however, less drastic (2 3 fold) according to our unpublished observation and others' publications.
These observations were further validated by quantitative real-time PCR (qRT-PCR) that clearly shows SA1 infection induced drastic (five-fold and above) overexpression of a set of proinflammatory genes, whereas SA2 infection moderately (less than five-fold) altered the gene expression.
In spring and early summer acoustic fish densities were low, followed by a drastic, 20-fold increase in late summer.
The difference in parasitemia was even more drastic (3.6-fold lower) between days 9 (4.6% vs. 16.9%) and 13 (12.2% vs. 43.6%), the post-ECM phase.
Similarly, siRNA-mediated knockdown of XIST resulted in a drastic (>10-fold) increase in the birth rate of male clones [ 47].
Besides, the mymA mutant of M.tb shows a drastic reduction (800 fold) in its ability to survive in the spleen of guinea pigs as compared to the parental strain [9].
In Spi3, an up to 45-fold strong induction of a cation efflux transporter was observed, accompanied by a drastic downregulation (106-fold) of an outer membrane porin.
The SOD-1 (G93A)PS line showed a drastic (about six-fold) drop in their copy number of the SOD-1 transgene when compared to normal SOD-1 Tg mice (Fig. 1b).
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