Sentence examples for drastic down from inspiring English sources

Finally, treatment of cells with HB-19 and Nucant constructs results in a drastic down regulation of surface/cytoplasmic nucleolin without affecting nuclear nucleolin.

Consistent with its higher activity as an antagonist of surface nucleolin, N6L treatment causes a drastic down regulation of surface but not nuclear nucleolin in a dose dependent manner.

Among all the miRNAs that were examined, miR-205 was identified as the most downregulated one by quantitative reverse transcription PCR (qRT-PCR), and level of miR-205 expression was found suppressed about 80% as compared with that in control samples, suggesting a drastic down regulation with the maximum inhibition (P<0.001; Figure 1a).

Additionally, in RASSF9−/− keratinocytes there was a drastic down-modulation of terminal differentiation markers, which could be rescued by infection with a recombinant adenovirus, Adv/HA-RASSF9.

The reactivation of the LKB1-AMPK-mTOR pathway under low energy conditions by the inhibition of BRAF signaling led to a more pronounced effect that included a drastic down-regulation of Mcl-1 (Fig 6).

Interestingly, when the LKB1-AMPKα pathway was restored under low glucose conditions, the increased number of dead cells correlated with a stronger biochemical response including the complete de-phosphorylation of Bad, the stabilization of the non-phosphorylated BimEL isoform and the drastic down-regulation of Mcl-1 (Fig. 5D).

Western blot analysis demonstrated a drastic down-regulation of NaPi-IIa in the proximal tubule, although metabolic acidosis as such may increase NaPi-IIa protein levels (Murer & Biber, 2010).

An early pioneering study on a Daphnia magna lake clone has demonstrated drastic down-regulation of two proteins involved in basic cytoskeleton reorganization processes, alpha tubulin and actin [ 7].

Secondly, data from our laboratory indicate that the perception of one sense leads to the drastic down-regulation in the expression of genes involved in sensing other, seemingly dissimilar environmental cues.

N/N ratios revealed that N-acetylated peptides with a NatB specific N-terminal sequence (ac-MDX, ac-MEX, ac-MNX) showed drastic down-regulation in the nat3Δ strain, verified in the biological replicate.

Unless he does something drastic like downing tools I can't see how he can go".