Sentence examples for drastic deleterious from inspiring English sources

That massive transposition that causes drastic deleterious effects is demonstrated by the well-known phenomenon of hybrid dysgenesis in Drosophila (Bingham et al. 1982; Bucheton 1990).

TDS could avoid a variety of disadvantages compared with the oral administration including drastic pH changes, deleterious presence of food and enzymes and first-pass effect of the liver.

Dr. Minugh-Purvis said it was unclear how the mutation could have become fixed in the species, given the potentially deleterious effects of any sudden, drastic change in a species' chewing and eating apparatus.

However, our findings do not support this hypothesis because drastic changes in IME1 levels had no deleterious effects on the efficiency of meiosis (Figures 3A, and 4B).

Such drastic changes in protein abundance are likely deleterious.

This version is designed to distinguish between mutations with drastic effects and other variations including abundant mildly deleterious alleles [ 17].

A continuous inbreeding experiment like the one we performed to reveal deleterious cryptic variation would be difficult with such drastic mutations, partly because homozygote offspring would be lethal.

Therefore, despite a drastic reduction in normal GR abundance, longstanding glucocorticoid excess may have deleterious effects through MR binding.

We found that deleterious interactions cause an increased variance in relative abundance, a drastic decrease in surviving lineages, and a rough expanding front.

One important implication of our work is that identifying and reconstructing a "youthful" stem cell niche may have long-term beneficial effects on tissue regeneration, in contrast to drastic modulation of a single cell-fate regulatory pathway, that could have deleterious side effects by promoting oncogenic transformation and/or inducing cellular senescence [ 14].

Deleterious effects can occur from leakage, including contamination of groundwater and subsurface resources and drastic changes to ecosystems [5 8].