Sentence examples for drastic defect from inspiring English sources

Single mutants have no impact, but the ΔRsmYZ strain results in a drastic defect in intracellular growth in A. castellanii and THP-1 monocyte-derived macrophages.

In contrast to HNF-1α, the renal-specific inactivation of HNF-1β develops polycystic kidney disease, and renal cyst formation is accompanied with a drastic defect in the transcriptional activation of several polycystic kidney disease (PKD -related genes, such as Umod, PKD -relatedand TgenesPolarisuch.

Indeed, even with only 50% stable knockdown of PAX3-FKHR in Rh30 cells, there is already a drastic defect in anchorage-independent growth.

A lack of individual ER-shaping proteins in unicellular organisms, such as yeast, causes no drastic defects.

Reasoning that less drastic defects in DBC2 might be even more common, the team looked for the gene's messenger RNA (mRNA) in cells from 56 samples of breast, lung, and colon cancer and in cells from 19 healthy tissue samples.

However, the orc5-1, fun30Δ double mutant showed what appears to be drastic defects in their cell cycle profile, with cells apparently accumulating in G1-early S phase with under-replicated DNA (genome content between 1n and 2n) and a substantial number of cells showing a genome content below 1n (Figure 3 B, orc5-1, fun30Δ).

This is in contrast with drastic defects observed in Arabidopsis upon downregulation of TIP1 1 by RNAi [ 30].

Thus, we did not screen for mutant strains with drastic defects of photosynthesis, but our screening procedure had to differentiate between oxygen-producing transformants and transformants which become anaerobic in the light.

Munc18-1, a hydrophilic protein with no inherent affinity for membranes, interacts with the t-SNARE syntaxin [17], [18] (for review see [19]) and (m)unc18-1 null alleles produced a drastic docking defect in mouse chromaffin cells [20] and a mild docking defect in nematode neuromuscular junctions [16], but not in mouse embryonic central nervous system (CNS) synapses [21].

These small reductions in Munc18-1 levels appear to be insufficient to explain the drastic docking defect.

Of the three mutations, Smc1 F584R has the most drastic binding defect.