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The phrase "drastic changes in" is grammatically correct and can be used in written English.
It is typically used to describe significant or severe alterations or modifications in a particular aspect or situation. Example: The new CEO implemented drastic changes in the company's policies, resulting in a major shift in the company's culture and operations.
Exact(60)
"She'll jump higher at 12," he said, barring drastic changes in body composition.
But the drastic changes in the feminine silhouette in the last 100 years tell the story.
Seiches, or temporary, sometimes drastic changes in the water level, can be observed.
And there might be drastic changes in the climate of some regions as ocean currents shift.
As an advancing lobe drags a cell forward, the same signals trigger drastic changes in the rest of the cell.
But it is the impetus for all these drastic changes in city government that has some residents angry.
5. Will we see drastic changes in the US women's player pool when all this is done?
But the Treasury is not expected to make any drastic changes in the way it does business.
To a certain extent, the judge's decision will not cause any drastic changes in Mr. Sweeney's daily life.
Not drastic changes to the story itself, but drastic changes in the way I told the story.
Using our testbed, drastic changes in available bandwidth were emulated.
More suggestions(15)
strong changes in
spectacular changes in
considerable changes in
radical changes in
vigorous changes in
harsh changes in
tremendous changes in
substantial changes in
drastic modifications in
severe changes in
dramatically changes in
far reaching changes in
drastic shift in
drastic modification in
sweeping changes in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com