Sentence examples for drastic cell death from inspiring English sources

Prolonged insulin resistance leads to an overload of the pancreatic cells which produce insulin, resulting in drastic cell death and diabetes.

Although pharmacologic inhibition of CKIε using PF-670462 and PF-4800567 alone did not result in drastic cell death, the involvement of CKIε in regulating an important factor in mitochondrial function presents the potential of targeting CKIε in enhancing response rates to chemotherapy.

Nevertheless, the very same treatment resulted in drastic Akata cell death, suggesting that the latter could not be prevented by the induction of hIL-10 expression.

Adenoviral transduction was highly efficient but its usefulness for gene delivery to rat exocrine cells in vitro was hampered by a drastic increase in cell death.

We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines.

Remarkably, removal from the culture medium of either Glucose or Aminoacid Supplement (Glutamine + DMEM Non Essential Aminoacids), the two main energy fuels for most cultured transformed cells [ 21], resulted in a drastic protection from cell death.

Examination of FADD expression in these cells following treatment with stress inducing agents revealed a significant upregulation in FADD expression positively correlating with the length of treatment, which may explain the absence of a drastic effect on cell death which we would expect to observe in absence of FADD.

Use of epirubicin and doxorubicin concentrations above 1 µM in combination with genipin resulted in drastic increases in the cell death of HL-60 and MX2 cells (data not shown).

Upon inhibition of wild-type p53 in these cells, they surprisingly responded with a drastic IGF-1R downregulation and cell death (Girnita et al, 2000).

This mechanism can no longer operate at high concentrations of the Ca2+-ionophore, which causes a decrease in mitochondrial and cytosolic hexokinase, leading to a drastic fall in ATP and melanoma cell death.

This drastic intracellular cholesterol reduction corresponds to the cell death induction by 10 µM simvastatin.