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Knocking out a gene need not have any impact on ontogeny due to genetic redundancy, while eliminating a particular cell or group of cells may dramatically interfere with normal development (Brigandt 2012, Mitchell 2009).
Therefore it is likely that post-translational modifications of HMGB1 will not dramatically interfere with its affinity for hcDNA.
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Geoengineering involves dramatically interfering with the Earth's systems – for example by injecting sulphur into the stratosphere to cool the Earth's surface.
The presence of 70% of EPR copolymer dramatically interfered with the iPP crystallisation process, as strong reduction in iPP crystallinity index (Xc) values is shown by both the iPP/EPR blends.
The investigation of these results shows that low levels of fluorocarbon contaminants readily react with the alloy surface and deposit a fluorine containing carbonaceous layer, which dramatically interferes with the adhesion of the plasma polymer to the alloys, but the adhesion with primer coatings remains tenacious.
The knockdown of FAK, while not affecting cellular proliferation or migration, dramatically interferes with vascular morphogenesis and survival, mirroring in vivo findings.
This showed that the stapling procedure did not interfere dramatically with the transport of classical anterograde cargo.
However, helminths can interfere dramatically with this critical process, suppressing the maturation of DCs following Toll-like receptor (TLR) ligation, reducing their production of inflammatory cytokines and reducing T cell responsiveness 86– 86.
In the case of killed vaccines, the pathogen is chemically inactivated to prevent its replication but not so dramatically as to interfere with the antigenic components of the pathogen, which then induce a more restricted immune response, although often sufficient to prevent disease.
Even so, nobody would dare to interfere so dramatically with Gloucester Cathedral today.
A 70% effective vaccine given to the general population would result in a significantly greater impact, interfering dramatically in the Brazilian epidemic by reducing the number of new infections from 2020 to 2050 by 92%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com