As a consequence, it is common to select variables that fit nicely the training set and fail dramatically on independent validation sets, thus leading to unstable gene signatures (Ein-Dor et al., 2005; Michiels et al., 2005) and poor prediction models.
Patients with mutations in the chromatin remodeling gene ATRX are clinically characterised by severe cognitive disabilities and muscular hypotonia, thus dramatically compromising their independent locomotory ability.
The informative genes selected by χ-IRG-DC could dramatically improve the independent test precision of other classifiers; meanwhile, the informative genes selected by other feature selection methods also had good performance in χ-DC.
This elevated basal phosphorylation resulted in a dramatically increased ligand-independent anti-apoptotic signaling and migration, as well as a ligand-dependent increase in proliferation of D849N-mutant mouse embryonic fibroblasts.
The significant shortfall in the funds for two United Nations aid appeals for Syria has dramatically changed since The Independent on Sunday revealed that Syria's Middle East neighbours had failed to deliver on promises made in Kuwait in January.
"The Guide to Navigating Through the Northern Sea Route," published in English in 1996 by the Russian Ministry of Defense, put the matter more dramatically: "Any attempt at independent, at vessel's own risk, transiting the NSR, without possessing and using full information, and without using all means of support, is doomed to failure".
When dis-joint relay selection is performed based on ES, the number of possible combinations of paths is dramatically reduced compared to independent selection scheme since the paths have to be dis-joint and not containing any common relay.
Nevertheless, our results do not change dramatically and are hence independent of the precise history of the plastid.
We found that the baseline of HIF-1α expression, which is oxygen independent, was dramatically up-regulated in arsenic-transformed cells.
Abbreviations: LPT, long-term potentiation; TT, taste transduction; OT, olfactory transduction; TCA, tricarboxylic acid cycle; CA, common ancestor of tetrapods and teleost fishes; 3R, third-round whole genome duplication; NA, not applicable A few genes were found to have expanded dramatically by repeated duplication independent of WGD.
