However, inhibition of cyclin B1 by siRNA knockdown along with irradiation dramatically increased the ratio of apoptotic population in cells with wild-type p53, but not in the cells with mutant p53 (Figure S5C).
While rapamycin failed to induce autophagy in primary neurons (data not shown), as reported previously [ 54], trehalose treatment for either 24 or 48 h dramatically increased the LC3B-II:LC3B-I ratio (~7-fold by 48 h) compared to vehicle (Fig. 10g h), an increase similar to that observed in the 5XFAD brain (Fig. 10a, b).
Obviously, reporting suicidal ideation in the past year dramatically increased the risk of suicide attempts (OR [odds ratio] = e2.78 = 16.18, 95% CI [confidence interval] = 9.36, 27.97).
Indeed, exogenous GC treatment dramatically increases the odds ratio of developing T2DM in humans (Lansang and Hustak, 2011).
We have developed Single Channel Array Normalization (SCAN), a single-sample technique that models the effects of probe-nucleotide composition on fluorescence intensity and corrects for such effects, dramatically increasing the signal-to-noise ratio within individual samples while decreasing variation across samples.
The significance of ensemble measurements is that they dramatically increase the signal-to-noise ratio, analytical precision and accuracy, and throughput of the PNR sensor.
Finasteride treatment targets the epithelium, with little if any effect seen on the stroma [ 34], and it dramatically increases the prostate stroma:epithelium ratio [ 28].
Using a microchannel with 3D prismatic silica elements on the wall can dramatically increase the surface area-to-volume ratio, and hence facilitate the nucleic acid adsorption on the wall.
