In the muscarinic acetylcholine receptor, disruption of this disulfide bond dramatically disrupts ligand binding.
The San Francisco-based startup is currently engaged in contentious legal battles with city governments across the country, and has become one of the most high-profile California tech companies to dramatically disrupt a longstanding industry, raising complex challenges for regulators.
Altered sphingolipid/cholesterol homeostasis would dramatically disrupt DRM architecture making them less ordered and more fluid.
Instead, he's looking for businesses that follow the firm's "Software eats the world" theory, where more and more industries are being dramatically disrupted by software solutions.
"People continue to be very pessimistic," said economist Dean Baker, co-Director of the Center for Economic Policy and Research, noting that economic conditions like the trouble in Europe could dramatically disrupt financial markets in the near future.
I believe intelligent machines will dramatically disrupt the human rights paradigm, and they will certainly require that we look at what it means to be human in new ways.
To my friend, the piano player, and to all of us musicians and singers who might feel overlooked in the shadow of a music business that has been so dramatically disrupted, take solace in the knowledge that our success cannot be gauged by quantitative measurements, as many other things can.
These data indicate that Schistosoma infection dramatically disrupts the host immune system.
Ectopic expression of the TCRα chain dramatically disrupts T cell development, resulting in reduced cell numbers and aberrant T cell populations.
siRNA-mediated depletion of p120 dramatically disrupts cell-cell adhesion and reduces the levels of E-cadherin and associated proteins at AJs [57].
