Sentence examples for dramatically decreases activity from inspiring English sources

The importance of this conformational activation is illustrated by the observation that mutagenesis of Arg283 and Glu295, which are >10 Å from the active site, dramatically decreases activity and the extent of conformational activation.

Breaking from the schedule in the final stretch felt unsettling, especially because long distance runners must taper during the last week of training, which involves dramatically decreasing activity to be in peak condition on race day.

The results indicated that while either single mutant was reasonably well tolerated, loss of both residues dramatically decreased activity.

Structure activity relationship studies carried out on three parts of the molecule indicated that the presence of a methylene or carbonyl group as a linker to the quinoline moiety dramatically decreased activity.

It was previously shown that transfection of carcinoma cells with anti-cofilin siRNA (Hotulainen et al. 2005) or overexpression of a constitutively active LIM kinase domain (Zebda et al. 2000) dramatically decreases the activity status of cofilin causing inhibition of cell motility (Yamaguchi et al. 2005).

Since viral proteins themselves are often translated via IRESes, expression of these proteases favors viral protein translation and dramatically decreases translational activity of the host cell.

Stabilization of MdmX by mutation of three serine residues to alanines (Mdmx Ser 341, Ser 367 and Ser 402) dramatically decreases p53 activity and increases reprogramming efficiency [ 126].

Prolonged oxidative damage also dramatically decreases telomerase activity and accelerates telomere shortening in vascular smooth muscle cells and endothelial cells [ 40].

Knock-down of endogenous ERα dramatically decreased the activity of the EBS-Luc reporters, activated by E2, in SH-SY5Y cells compared with control (Fig.  3b).

Incubation with MGO dramatically decreased the activity of luciferase, suggesting a strong decrease in HIF-1 transcriptional activity.

After chilling treatment, all transgenic lines maintained higher SOD activity steadily in comparison to the wild-type plants that showed dramatically decreased SOD activity over 5 days of chilling treatment.