Sentence examples for dramatically decreased activity from inspiring English sources

The results indicated that while either single mutant was reasonably well tolerated, loss of both residues dramatically decreased activity.

Structure activity relationship studies carried out on three parts of the molecule indicated that the presence of a methylene or carbonyl group as a linker to the quinoline moiety dramatically decreased activity.

The importance of this conformational activation is illustrated by the observation that mutagenesis of Arg283 and Glu295, which are >10 Å from the active site, dramatically decreases activity and the extent of conformational activation.

Breaking from the schedule in the final stretch felt unsettling, especially because long distance runners must taper during the last week of training, which involves dramatically decreasing activity to be in peak condition on race day.

Knock-down of endogenous ERα dramatically decreased the activity of the EBS-Luc reporters, activated by E2, in SH-SY5Y cells compared with control (Fig.  3b).

Incubation with MGO dramatically decreased the activity of luciferase, suggesting a strong decrease in HIF-1 transcriptional activity.

After chilling treatment, all transgenic lines maintained higher SOD activity steadily in comparison to the wild-type plants that showed dramatically decreased SOD activity over 5 days of chilling treatment.

Results from this study revealed that constipation dramatically decreased the activity of daily living and compromised the quality of life for PD patients.

For example, children who were placed shortly after birth into orphanages with conditions of severe neglect show dramatically decreased brain activity compared to children who were never institutionalized.

Several factors contribute to accelerated diabetes epidemic in Asians, including the "normal-weight metabolically obese" phenotype; high prevalence of smoking and heavy alcohol use; high intake of refined carbohydrates (e.g., white rice); and dramatically decreased physical activity levels.

The side chain of Glu-462 that forms hydrogen bonds with the glucose moiety of DIMBOA-Glc moved deeper into the pocket upon substrate binding, and mutation of this residue dramatically decreased enzyme activity.