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However, the Akt response to insulin was dramatically blunted in the tissues derived from the Tsc1−/− mice.
Multiple comparisons performed on OSS data revealed that heterozygous mice had a significant (p<0.05) elevation in responding relative to wildtypes, while knockout mice had dramatically blunted responding (p<0.001).
However, hDAT N64 pull down of STX1ΔTM S14A was dramatically blunted.
In mouse models of endotoxin tolerance, IL-6 and IFN-γ released in the circulation following an LPS challenge are also dramatically blunted, whereas this is not the case for IL-12p70, and the chemokines KC and MCP-1, the circulating levels of which were reduced but not as much as TNF and the previously mentioned cytokines [ 11].
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"You can really dramatically blunt the risk of having flares," said Dr. H. Ralph Schumacher Jr., a professor of medicine at the University of Pennsylvania who is a consultant to Regeneron.
cAMP was, however, in all instances able to dramatically blunt the effects of TGF-β1.
Strikingly, the final outcome at the cellular level is similar, albeit through completely different molecular mechanisms: a reduced mitochondrial Ca2+ overload upon pro-apoptotic stimuli that dramatically blunts the apoptotic response.
The neuronal potassium channel subunit Kcnj9 knockout mice exhibited blunted morphine-induced analgesia [ 32] and dramatically reduced intravenous self-administration of cocaine [ 49].
His eyes looked blunted.
Weapons must be blunted.
Flavors are blunted.
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