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Remarkably, ATP and related compounds were later found to dramatically activate the hydrolysis of shorter substrates by as much as ∼70-fold [24], [29].
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We found that Src was dramatically activated during platelet activation and, because platelets don't have a nucleus, we knew that it couldn't be regulating proliferation.
We find that OPA1-S1 cassembleble on lipid surfaces, and this interaction dramatically activates its GTP hydrolysis activity.
Along with the ChIP-chip data [ 24], one group recently suggested that CREB1 is able to bind the CRE site (CGTCA ; −921 to −917 ) on the Atf4 promoter and a constitutively active PKA catalytic subunit dramatically activated Atf4 promoter through PKA-CREB1 signaling [ 23].
The lack of phosphate also dramatically activates the expression of pqsR and the PqsR-regulated pqsABCDE and phnAB genes.
As predicted, ERRγ dramatically activated YY1 promoter, which was repressed by expression of SHP (Figure 4a).
Furthermore, a report using chemical inhibitors indicated that ERK pathway via PRKD1 was dramatically activated by Tat in monocytes [36].
FAC also dramatically activated the MAPK and PI3K pathways in HEY cells.
All six ABA-inducible genes were dramatically activated by the ABA treatment in wild-type plants.
Furthermore, we found p38 pathway was dramatically activated by MDK after one hour treatment, while c-jun NH2 terminal kinase pathway was not activated (data not shown).
As shown in Figure 4a, GRP78 and all three ER stress sensors, IRE1, PERK and ATF6, were more dramatically activated in DCM compared with Ctrl and NAC.
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CEO of Professional Science Editing for Scientists @ prosciediting.com