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PLGA CS PEG nanoparticles showed dramatic prolongation in blood circulation, as well as reduced macrophage uptake, with only a small amount of the nanoparticles sequestered in the liver, when compared to PLGA CS and PLGA nanoparticles.
Consistent with the severe mitotic phenotypes observed, live cell imaging showed that EGFP-Hec1 cells experienced a significant lengthening of the time spent in mitosis with a dramatic prolongation of the cytokinesis time (Figure S3D).
Prior to BT injection, the ADSD speakers (middle panels) exhibit dramatic prolongation of their phrases, taking more than twice as much time as their normal counterparts.
Full I Kr block induced an even more dramatic prolongation of APD90, +90% and more for both hiPSC-CMs, and for hAdultV-CM, early after depolarizations (EADs) were triggered.
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Combined treatment with everolimus and gefitinib produced a dramatic survival prolongation not only in GEO but also in GEO-GR-xenografted mice, in fact at the end of the experiment, 80% of mice were still alive.
Bevacizumab is commonly combined with cytotoxic chemotherapy and resulted in dramatic improvement on radiographic images, prolongation of progression free survival and less need for corticosteroids [4].
Elimination of Gβ5 also resulted in dramatic slowing of GIRK channel deactivation kinetics, prolongation of synaptically-evoked slow IPSCs in hippocampal pyramidal neurons, and increased behavioral sensitivity to GABABR stimulation (Xie et al., 2010).
The PBPK-QTc modeling would likely suggest an appreciable QTc prolongation with terfenadine alone and a dramatic QTc prolongation in the presence of ketoconazole mirroring described clinical experience.
Propensity-score matched analysis revealed a dramatic rise in hospital mortality (mean excess 17.7% [SE 1.3%]), LOS prolongation (mean excess days 16.5 [SE 2.2]) and costs (mean excess costs $64,526 [SE $7,805]) associated with a diagnosis mucormycosis.
Dramatic, dramatic, dramatic!
Very dramatic".
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