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Dramatic perturbations of ecological communities through rapid shifts in environmental regime do not always result in complete mortality of residents.
In fact, centrioles are capable of robust self-assembly and can tolerate dramatic perturbations while still maintaining basic functionality.
This is in close agreement with mutagenesis and functional studies: residues Y511, S512 and T550 identified in these studies locate right around the pocket (Jordt and Julius, 2002; Gavva et al., 2004), and dramatic perturbations to intracellular structures often leave capsaicin activation undisturbed (Ma et al., 2016).
For dramatic perturbations, the minimum duration of perturbation to induce switching is approximately set by the cell division time.
Sirt1 knockout mice are also markedly smaller than their littermates, develop more slowly and show dramatic perturbations in eye morphogenesis and cardiac septation [ 79].
However, the α-helix conformation could also facilitate membrane insertion and channel/pore formation, leading to dramatic perturbations of membrane permeability, as shown for α-synuclein (Ref. 69).
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Dramatic perturbation is evident in the expression trends of members in all three classes in the ES (GCNF−/−) mutant.
This causes a dramatic perturbation to the vesicle and leads to a gradual reduction of GUV size.
A dramatic perturbation of the Cdc28-Swi4 sentinel PPI was observed in Δelm1 and Δclb2 in that there was no signal above the autofluorescence threshold in either strain (P = 0.0002).
It indicates that the exercise-stress cause dramatic perturbation of gene expression in muscle in response to the stress in the tissue.
While addition of osteogenic medium produced a dramatic perturbation of the developmental program, magnitude of transcriptomic responses to adipogenic stimulation was small and gradually increased to the end of the experiment as might be expected for committed cells.
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