Based on our recent work describing the phenotypic dichotomy between migratory and stationary glioma cells, dramatic differences in pathway activation as depicted by the lack of overlap in the pathway enrichment analysis between the two signatures are not unexpected [ 6, 36].
For the HETEs, compounds biosynthesized via the LOX pathway, a dramatic increase was visible, in particular for 12-HETE and 5-HETE (Fig. 7).
An emerging field is the investigation of the redox chemistry driven by some transition metals which can result in dramatic consequences for metabolic pathways.
The impact on the J and NJ data is more dramatic; all IL23R containing pathways are no longer significant.
Hp provides structural stabilization of Hb and shields Hb's oxidative reactions with lipoproteins, providing dramatic protection against both pathways of toxicity.
These basic cell death pathways show dramatic sexual dimorphism, suggesting mechanisms that may underlie the differences in outcome of brain injury (Golomb et al., 2008).
In contrast, apelin knockout animals exhibit increased myocardial injury and dramatic suppression of prosurvival pathways resulting in greater cardiac dysfunction (Wang et al., 2013b).
Alternatively, both the XR/XDH and XI/XK xylose utilization pathways cause dramatic transcriptional remodeling of the cell (Bengtsson et al. 2008; Fendt and Sauer 2010; Hector et al. 2009; Jin et al. 2004; Pitkanen et al. 2003; Runquist et al. 2009; Salusjarvi et al. 2008; Salusjarvi et al. 2003; Wenger et al. 2010).
Kenneth Gloag, in his detailed analysis of the oratorio, writes: "As well as constructing the pathway through the dramatic narrative, the five spirituals also combine to provide moments of focus and repose... giving shape to both the musical and literary dimensions of the work".
Downstream activation of the IRF3 pathway results in dramatic upregulation of RIG-I expression and signal amplification.
