His mid-1970s analysis of a dramatic mutation occurring within contemporary societies and rise of a new mode of simulation, which sketched out the effects of media and information on society as a whole, is also original and important.
One dramatic mutation, I53D, results in the conversion from a three-state to a two-state folding mechanism, which is explained most easily through a simple destabilization of the kinetic intermediate such that it is no longer stable with respect to the unfolded state.
As a lived tradition, Islam is constantly undergoing dramatic mutation.
This elegant monograph traces "dramatic mutations" in the concept from Jesus to Augustine, along with changing ideas about time, the cosmos, the devil, divine justice, and the human body.
Using new statistical methods, they have found many less dramatic mutations that, for example, also help highland Tibetans survive at high altitude.
p.Gly162Asp is one of the most dramatic mutations we identified because it introduces a negative residue inside the hydrophobic core.
My suggestion is that the sudden expansion of the brain 200,000 years ago was a dramatic spontaneous mutation in the brain of Mitochondrial Eve or a relative which then spread through the species.
Whole genome duplication (WGD), or polyploidization is a rare, but dramatic genetic mutation event which doubles the size of a genome and creates a redundant pair of copies from every gene.
For example, Endicott and Ho [ 4, 12] observed dramatic differences in mutation rates, mutation saturation, and selective effects in different partitions (e.g., first, second and third codons, D-loop, rRNA) of human mitochondrial genomes; similar findings have been reported by Ingman and collaborators [ 13], also in humans, and by Subramanian et al. [ 5] in Adélie penguins (Pygoscelis adeliae).
This observation shows that this position in CAM1 can be mutated without major consequences upon catalytic efficiency, which contrasts with the dramatic effect that mutation of Ser81 in PriA, even into a highly similar amino acid such as threonine, has upon its isomerase activities (between one and two orders of magnitude; Fig. 4).
When PCR mix II was supplemented with SYTO-9, SYTO-13, EvaGreen, LCGreen or ResoLight, no dramatic changes in mutation frequencies were observed (Table 3).
