Thus, these results have clearly evidenced that the benefit of the multidrug nanoassemblies resulted from a dramatic modification of the pharmacokinetic and biodistribution profiles of the two biologically active compounds, in comparison to their administration just as free drugs.
The deposition of quartz as pore-filling cement and/or veins is a common diagenetic process during burial sedimentation, and can cause dramatic modifications of bulk-rock mechanics, including changes in stiffness (Laubach et al. 2004), consolidation behavior (Karig and Morgan 1994), and frictional properties (Lockner and Byerlee 1986).
This impairment, characterized by a generalized immune activation and a CD4 T-cell depletion has, as consequence among others, a dramatic modification of cytokine and chemokine profiles [22], [23].
It reveals dramatic modifications in the transcriptional profiles selected in resistant larvae, with a global transcriptional increase of genes coding for proteases and chitin-binding proteins, and a decrease in transcription of genes involved in detoxification and immunity.
The organization of the anthocyanin inclusions present in BMS35S::R+35S::cellslls undergo dramatic modifications in the presence of light.
Without dramatic modification, the current adjustment methods will not adequately control for bias, and the controversy will undoubtedly continue.
These results indicate dramatic modifications in cell shape and organization that neutrophils are capable of performing.
Major epigenetic changes during mitosis of somatic cells could be catastrophic for the organism, and we did not expect dramatic modifications.
Dramatic evolutionary modifications of functional V gene germline repertoires are assumed to reflect selective pressures exerted on the adaptive immune system and in turn result in beneficial changes in the expressed TR repertoires.
