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Figure 2 shows that single or repeated treatment with NTHi lysate induces dramatic inflammation in the lungs, measured by cytokine levels (Fig. 2A) and cellular influx (Fig. 2D).
In the case of MAV-induced nephroblastomas which represent a unique model of Wilms' tumor [ 40], we observed that viral infection of tissue targets induced a dramatic inflammation of the cortical region of the kidneys.
Of note, it was only possible to detect small foci of leukocyte infiltration in other organs such as the liver, the spleen and the lymphnodes, but not the skeletal muscle, showing that the dramatic inflammation observed is specific to heart striated muscle and ruling out the involvement of a systemic inflammatory disease (Supporting Information Table S1).
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They activate immune cells, such as macrophages and neutrophils in the host and in turn, the stimulated cells synthesize proinflammatory factors, such as IL-1β and TNF-α, matrix proteases and free radicals and thus lead to dramatic secondary inflammation in tissues [ 13, 14].
One of the ways this works is through a dramatic decrease in inflammation.
During acute infection and inflammation, dramatic shifts in tissue metabolism are typical, thereby resulting in profound tissue hypoxia.
Another marked feature of obesity is the dramatic upregulation of Inflammation and macrophage-specific genes in AT [ 1].
Importantly, reducing tau levels recovered the BBB defect, demonstrating its remarkable resiliency, even in the face of dramatic degeneration and inflammation.
For this reason, at the anti-inflammation stage cells need to make use of the negative regulator proteins and cytokines to inhibit the function of some dominant cross-talks to recover from the dramatic activations in inflammation.
The topical application of bioactive products derived from n-3 fatty acids has conferred dramatic protection against inflammation-induced tissue and bone loss associated with periodontitis in experimental models (Naqvi et al. 2010).
Fat type had a dramatic effect on WAT inflammation: the number of crown-like structures (CLS; indicative of macrophage abundance in adipose tissue and WAT inflammation) (Cinti et al., 2005) and accumulation of CD45+ cells (leukocytes) in WAT increased dramatically between 3 and 11 weeks on a lard diet, whereas fish oil did not induce inflammation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com