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The static nature of the story may be a mild dramatic drawback — even though the show clocks in at a brisk 70 minutes — but it's an all-too-apt expression of the interior world of a high school freshman looking at four years of the loneliness and despair that have become his everyday companions.
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Historically, exogenous administration of hemoglobin solutions to implement the oxygen transport capacity for clinical applications suffered from dramatic drawbacks, resulting in the failure of many attempts.
But that's just a technical problem; Amazon's blog subscriptions have two far more dramatic drawbacks.
Such an approach could allow for the pursuance of fossil fuel utilization without the feared drawback of dramatic climatic changes.
Repetitive controllers are usually designed assuming a fixed frequency for the signals to be tracked/rejected, its main drawback being a dramatic performance decay when this frequency varies.
A key assumption in traditional repetitive control designs is that the frequency of such signals is constant and known, its main drawback being the dramatic loss of performance that occurs when this frequency is uncertain or time-varying.
If towers can sometimes look dramatic and impressive, they also bring drawbacks.
However, this 'off-label' practice, which has never been proven to be effective, has important drawbacks, such as a dramatic increase of treatment-related costs and a potential yield of treatment-related adverse events.
This was a dramatic indication to the colonists of the drawbacks of the Spanish monopoly, especially when that monopoly was exercised by what was, in European terms, an underdeveloped country.
However, although short-lived FPs can report changes more faithfully, they have a major drawback in that they show a dramatic decrease in the fluorescent signal since much less FP is left for detection.
In fact, it was even lower than that of the "plus-minus" method developed in 1975 by Sanger and Coulson [ 21], but a dramatic increase in sequence data output compensated for this drawback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com