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Disruption of the Hippo pathway, including major components Hippo, Salvador, and Warts, results in aberrant follicle-cell differentiation and proliferation and dramatic disruption of the oocyte anterior-posterior axis.
Conversely, Harlow et al. [ 15] showed dramatic disruption of the culturable microbiota concurrent with increased shedding of enteropathogens after administration of TMS or ceftiofur sodium in horses.
Another positive-strand RNA virus, the poliovirus, induces dramatic disruption of the Golgi with consequences for the secretory complex [ 26, 27].
Latrunculin B treatment for 5 to 25 minutes resulted in dramatic disruption of the actin cytoskeleton, which was evident by phalloidin staining (Fig. 2I; supplementary material Fig. S2D,F,H).
A major challenge with addressing the contribution of individual side chains in the selectivity filter and pore helix to slow inactivation is that many amino acids lack naturally occurring analogs that allow subtle manipulation without dramatic disruption of the overall structure of this critical protein region.
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Taken together, these experiments show that neither of the ionophores caused dramatic disruptions of the apicoplast DNA replication or protein import.
No clear trend emerged; however, que mutants consistently show the most dramatic disruption of swimming behavior compared with acc or beo mutants.
Very little myomesin staining could be detected in the hsp90α1 mutant embryos (Fig. 8D), suggesting that the hsp90a1 mutation could result in a dramatic disruption of M-line organization in skeletal muscles.
More importantly, we had discovered dramatic disruption of BBB in S89G-DMP1 mice.
MPTP injection yielded a dramatic disruption of sleep wake architecture with reduced sleep efficacy that persisted years after MPTP administration.
PTEN knockdown also causes a dramatic disruption of normal tight junction formation in adherent mammary epithelial cell cultures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com