Exact(3)
These are clusters that show a dramatic destabilization of mRNA (see Fig. 4 & Fig. S1) that contributes with TR downregulation to a rapid decrease of mRNAs.
Furthermore, truncation mutations of TRBP are found in carcinoma and associated with both decreased miRNA levels, as well as dramatic destabilization of Dicer [ 155].
Substitution of the large, hydrophobic, and aromatic Trp184, which is deeply buried in the helix 2 region by the small Ala, not only weakens the hydrogen bonds, side chain contacts, and π-stacking, but also disrupts compact geometrical packing, causing a dramatic destabilization of the CA dimeric interface as well.
Similar(56)
More dramatic destabilizations were required to obtain data at pH 7.
Moreover, MGO-induced destabilization of HIF-1α led to a dramatic decrease in HIF-1 transcriptional activity.
In this scenario, the C5A-mediated destabilization of the membrane would have a more dramatic effect on a viral than a cell membrane.
The mutation effect on Rev structure, which is destabilization of the protein structure, is manifest as a dramatic reduction in Rev activity in CAT-based assays.
The impact of HIV and AIDS has led to the disruption and destabilization of families and communal support systems and a dramatic increase in the number of vulnerable children and child headed households; with the impact on households often leading to disintegration as assets are depleted to cover medical and burial costs.
But there's the destabilization the baby brings, and then there's another kind Karen's expectation that this dramatic life change will alter her emotional landscape completely, and her disappointment at finding out that she still has to keep herself company.
More alarming: Climate destabilization.
Dramatic, dramatic, dramatic!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com