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This dramatic defect is not due to alteration in Spt16p expression or chromatin occupancy in the mutant cells (Fig. S2).
Our behavioral experiments showed that feeding inhibition evoked by 1% 1-octanol had a dramatic defect in the ser-2 mutant, which is involved in central integration of feeding (Li et al. 2012).
Thus, although hSgo1-depleted cells had a dramatic defect in the ability to hold sisters together, Rad21-depleted cells did not.
CI performed with the mutant hldA (strain SAL1) produced the lowest CI observed, with a low mean result of 0.005 and a dramatic defect in in vivo survival.
Similar to ICOS−/− mice, ICOSL−/− mice had no defect in naïve cell numbers and a dramatic defect in EM phenotype CD4 T cell numbers (Figure 1C).
Thus, the eif3h mutation causes no dramatic defect during the first stage of post-meiotic pollen development, the stage that encompasses the two subsequent mitotic divisions that result first in one vegetative nucleus and then the two sperm nuclei [34].
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Any play in which defecation is used to cover up dramatic defects.
APP−/−APLP2−/− animals show dramatic defects in the development of NMJ [29], [31].
Interestingly, the over-expression of Lbe also leads to dramatic defects in muscle performance.
Mouse alpha neurexin mutants show dramatic defects in calcium-dependent neurotransmitter release [50], [53].
Their down-regulation led to dramatic defects in chromosome congression/segregation frequently accompanied by mitotic spindle elongation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com