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Continuous exposure of DDT1 MF-2 smooth muscle cells to 10-100 microM norepinephrine results in a dramatic attenuation of the ability of norepinephrine to stimulate inositol phospholipid hydrolysis via alpha 1-adrenergic receptors (alpha 1-AR).
The synthetic seismograms of the vertical ground motion component along the profile across the crustal barrier demonstrate the dramatic attenuation of the Lg wave energy as it crosses the Sea of Japan over a 1,400-km 1,400-km from the hypocenter onwardistance
Furthermore, ablation of PC boutons induced a dramatic attenuation of PNNs.
Pre-incubation of the serogroup B meningococcal CPS-lpxA polymers with the human cathelicidin LL-37 resulted in dramatic attenuation of CPS bioactivity.
Since transcription factors typically regulate multiple genes, dramatic attenuation of an expression of four DTFs could have a major impact on biological function in ccRCC.
As control, cells were pre-treated with thapsigargin for 30 min and then stimulated with A23187 in the absence of extracellular calcium, observed a dramatic attenuation of the release of calcium from the ER by thapsigargin tretament (not shown).
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We demonstrated that mutations in either the PMT1 or PMT4 genes result in dramatic attenuation in virulence in both a macrophage killing assay and a mouse inhalation model of cryptococcosis, two models that assess different aspects of cryptococcal pathogenesis.
This decrease in IFN-I inhibitory function in cell culture would explain that infection of mice with both the deletion mutants and the IFNα/βBPGAGmut expressing viruses resulted in a dramatic attenuation phenotype compared to WT virus infections.
Similar relationships were observed for fasting insulin, with more dramatic attenuation by eGFR.
Comparison of expression fold changes of the top 15 connected genes in the black module during the progenitor to neuron transition are shown in Figure 3C, demonstrating the dramatic attenuation in differentiation related expression changes in patient versus control neurons.
In contrast, in the hph-1 mouse, in which tissue BH4 levels are decreased by up to 90%, attenuation of DHFR activity leads to dramatic changes in biopterins and consequently NO and superoxide production by eNOS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com