Sentence examples for dramatic alterations in gene from inspiring English sources
To determine the underlying mechanism behind the dramatic alterations in gene expression observed in the RB-deficient p53DD, recurred cells, we first examined the locations of the gene changes across the mouse genome.
In contrast, the RB/p53-deficient cells that had been treated with CDDP (Cre Recurred) displayed dramatic alterations in gene expression not observed in any other cell population (Figure 3C).
In this report, we elegantly demonstrated that UN-induced renal injury is associated with dramatic alterations in gene expression profile, as presented on the depicted drawing (figure 4).
During the stringent response process, an accumulation of the signaling nucleotides pppGpp and ppGpp occurs, which causes dramatic alterations in gene expression [ 42].
Nonetheless, dramatic alterations in gene expression are elicited with the greatest enrichment of differential expression found in pathways associated with cellular differentiation and growth, cell signaling and metabolism, and defense signaling.
The effect of removing tissue-specific regulators for a specific pathway leads to dramatic alterations in gene expression and often a block in differentiation at the point where this factor is crucially needed.
In light of this, it is not surprising that gene expression microarrays revealed dramatic alterations in global gene expression profiles of several organs such as skeletal muscles and adipose tissue [ 3], intestine [ 4] and the liver [ 5] both in type 1 and type 2 diabetes.
In monaural condition, all subjects showed a dramatic alteration ins their abilities to localize a sound source in azimuth.
UN induced dramatic alterations in expression levels of more than 200 genes, mainly up-regulated, including oxidative-response related genes, genes encoxidative-response relatedism, ribosomal proteins, sigenestransduction, and solute transporters.
Based on our experience in studies of hormone-therapy resistance in breast cancer, antiestrogen resistance is accompanied by dramatic alterations in the expression level of many genes, and alteration of DNA methylation may be one of the causes.
Great interest in the roles of Wnt signaling on bone mass followed the 2001/2002 discoveries that various LRP5 and SOST gene mutations in humans are responsible for dramatic alterations in patients with osteoporosis pseudoglioma, the HBM phenotype, sclerosteosis and van Buchem's disease.
