Though the producers of a flop 1970 Broadway musical starring Rita Moreno (the big number was called "We're Sharin' Sharon") still controlled the dramatic rights, agents for the Lewis estate were willing to carve out a "limited permission" for the opera, including the condition that it not include one word of spoken dialogue.
Accorsi, after exhaustive investigation, completed the biggest and most dramatic free-agent acquisition in the modern history of the Giants.
In an open-label, multicenter trial, Jagannath et al demonstrated dramatic single agent activity of carfilzomib in patients with relapsed and refractory multiple myeloma.
The ensuing clinical success was so dramatic that these agents were hailed as miracle drugs.
Optical imaging is receiving much attention with dramatic innovations in reporter agents, applications and methods.
DOI: http://dx.doi.org/10.7554/eLife.04640.002 The inhibition of key oncogenes with target-specific agents elicits dramatic initial response in some cancers such as prostate cancer and melanoma (Bollag et al., 2010; Clegg et al., 2012).
Recently, tyrosine kinase inhibitors targeting epidermal growth factor receptor (EGFR), gefitinib and erlotinib, have been introduced into the therapy of NSCLC, and experimental and clinical studies have revealed that these agents induce dramatic antitumor effects for tumors with activating mutations within the EGFR kinase domain.
CoQ10 is the most commonly prescribed antioxidant in mitochondrial disease, although a randomized placebo-controlled double-blind crossover clinical trial did not reveal dramatic efficacy of this agent (Glover et al., 2010) as discussed above.
But nothing compared to what happened after 9/11, which led to a dramatic increase in Border Patrol agents.
"Those are things that we'll pursue and try to put together, and I don't anticipate our being involved in any of the premium free agents, unless something dramatic changes".
