Sentence examples for dramatic affinity from inspiring English sources

This dramatic affinity increase due to polypeptide conjugation was achieved for a small molecule ligand with an already high affinity to the target protein.

Evaluation of the changes in constant pressure heat capacities during binding suggest that solvent exclusion from the binding site does not account for the dramatic affinity enhancements observed.

In contrast, putative cyanobacterial genes in diatom genomes show a dramatic proportional affinity to red algae against all control groups, and differences are significant in five of six cases (Table 2).

A dramatic reduction in affinity was also observed for the peptide QPQQPY, such that the affinity of the anti-33-mer G12 moAb decreased as follows: QPQLPY>QPQLPF≫QPQLPL>QPQQPY.

Addition of a meta-hydroxy group to the thiophenol moiety of Arbidol to replace a structured water molecule in the binding pocket resulted in a dramatic increase in affinity against both H3 1150-foldd) and H1 (98-fold) hemagglutinin subtypes.

Compared with wild-type BmKKx2, BmKKx2-K18A and BmKKx2-R20A exhibitedramaticic drop of affinity on hERG channels for 56- and 61-fold, respectively.

Strikingly, mutation of A11 to any of the three other nucleotides resulted in a dramatic loss of affinity of ERFs to the GCC box.

Through a series of controls, we showed that this dramatic enhancement in affinity is indeed the result of bidentate binding by the two component aptamers.

The mutant proteins also showed a dramatic decrease in affinity for their interaction with yPam18 and human Pam18 ortholog DnaJC19 proteins; envisioning a similar defect in subcomplex formation in human mitochondria.

The dramatic loss in affinity clearly indicates the requirement of both residues for binding of IL-13 to IL-4Rα, which has also been shown previously in a more qualitative cell-based measurement [ 37].

Binding to the receptor formed from IL-13Rα1 and IL-4Rα leads to a dramatic increase in affinity (KD ~ 30 – 40 pM), suggesting a strong cooperativity for binding to both receptor subunits (Fig. 1b) [ 15].