These morphological differences were accompanied by dramatic differential adhesion properties.
Previous studies have shown that global N-cadherin mutant embryos contain dramatic cell adhesion defects in the primitive heart where cardiomyocyte dissociation occurs even though myocardial tissue forms initially, thus resulting in eventual failure of the heart tube to form normally.
(c) Same experiment in the presence of free heparin (50 μg/ml) demonstrating a dramatic reduction of adhesion frequency due to the blocking of the HBHA adhesion sites.
Then the air flow rate increases though the wavy top of transverse ridges, inducing the dramatic decrease of adhesion force.
(c) Control experiment showing a dramatic reduction of adhesion frequency when the force measurements are performed in the presence of free d-Ala-d-Ala-d-Ala peptides.
Inhibition of CBEL gene expression in transgenic P. parasitica strains led to a dramatic reduction in adhesion of the mycelium to cellulosic substrates [69].
The specificity of these analyses was confirmed by showing a dramatic reduction of adhesion events in the absence of Ni2+, or on related yeast strains lacking the sensors [14].
Activation of PMN leads to dramatic changes in adhesion to endothelial surfaces to promote diapedesis and PMN exit to the site of injury or infection, mediated in part by upregulation of integrins CD11b and CD18 and shedding of L-selectin (CD62L) from the cell surface [ 26].
Topography at the nanoscale can lead to dramatic changes in the adhesion of cells to surfaces and their subsequent viability.
In fact, the global optimum is not considered to be the most desirable value as a small variation from the minimum causes a dramatic increase in the adhesion requirement.
