Expanding PLN have normal B cell follicles and T cell zone, with dilated paracortical sinuses filled with lymph that are mostly free of cells, suggesting active draining function.
Equally important is the availability of new methods to assess lymph node (LN) draining function and lymphatic flow in vivo, which have the potential to serve as biomarkers of arthritic flare and response to therapy.
The observation that asymmetric PLN collapse occurs concomitantly with arthritic flare in the adjacent knee, leads to the prediction that there also must be asymmetry in lymphatic draining function in the lower limb.
In collapsed PLN, the architecture of the B cell follicles and T cell zone are totally disrupted by B-in translocation into the paracortical sinuses in the center of the node, consistent with decreased draining function.
Bearing in mind the draining function of regional lymph nodes at sites of peripheral infection, early accumulation of PrPTSE in the ipsilateral Ln. popliteus of our footpad-infected model animals is not surprising.
In many ways the island is like a toy village, its real buildings drained of function and population.
When I went to visit him, he was particularly drained, a function of the treatment as much as the cancer itself.
As you fight to get your students to pay attention, or try to make yourself useful as your team scurries about with building materials, you start to feel too drained to function.
In our patient, we identified a remarkably tortuous, small draining vein functioning as a collateral vein from the mesenteric varices to an abdominal wall vein on contrast-enhanced CT scans and in the venous phase of superior mesenteric arteriography.
We identified a remarkably tortuous small draining vein functioning as a collateral vein from the mesenteric varices to an abdominal wall vein on contrast-enhanced CT images and in the venous phase of superior mesenteric arteriography.
