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Extracted data included the clinical characteristics of participants, study design, and follow-up, assessment of DR, and the number of participants who had the outcome according to DR status.
Sub-analysis by diabetic retinopathy (DR) status revealed these variants were associated with ADMA levels predominantly in participants without DR. Combined analysis of the most strongly associated SNPs in DDAH1 (rs669173) and DDAH2 (revealed3) reveaned additiveiveffectct (p = 1.37×10−8) on ADMA levels.
We obtained the most recent DR status, HbA1c, cholesterol, sBP and dBP levels for this study.
The associations of glycemic measures with DR status were examined cross-sectionally.
* P- Value for difference in characteristics by Diabetes Retinopathy (DR) status, based on chi-square test, Fisher's Exact, Mann-Whitney or t-test, as appropriate.
Of particular interest, rs1617640 (EPO) was not significantly associated with DR status, combined SDR DN phenotype, time to SDR or time to DN (all P > 0.05).
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Meanwhile, in Japan, a higher frequency of advanced fibrosis without a change in HLA-DR status has been reported in elderly AIH patients [ 14].
All of these statistical analyses were also performed for HLA-DR status, considered alone or in combination with the TNFRII 196R allele.
The density of the leukocytic infiltrate was higher in carcinomas than in either normal breast tissue or benign lesions, the HLA-DR phenotype of the mononuclear infiltrating cells lacking any obvious correlation with the HLA-DR status of the epithelial component.
We requested individual participant data regarding presence and severity of DR, DME status, age, sex, ethnicity, diabetes type and duration, hemoglobin A1c (HbA1c), systolic and diastolic blood pressure, lipid profile, cigarette smoking status, BMI, and current use of diabetes, antihypertensive, and lipid-lowering medications.
Blood samples were collected within three to five days after the initial determination of the patients' monocyte HLA-DR expression status.
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