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Enhanced expression of miR-155 in RA synovial fibroblasts revealed matrix metalloproteinase 3 (MMP-3) as a potential target of miR-155, suggesting that miR-155 may modulate downstream tissue damage (Stanczyk et al., 2008).
Taken together, these results suggested that changes in the mechanical environment of the bladder trigger synthesis of soluble growth factors by the bladder cells, which induce downstream tissue remodeling.
Arterial occlusion results in ischemia of the downstream tissue, which cause myocardial damage and necrosis.
In traditional methods of animal experiments, Doppler perfusion imaging is often performed on downstream tissue, as an indirect measure of vascularisation.
This condition is, however, associated with the formation of new blood vessels (angiogenesis) and remodelling of preexisting collateral arterioles (arteriogenesis), which reestablish blood flow to the downstream tissue (Schirmer et al, 2009; Simons & Ware, 2003).
To assess the extent of downstream tissue remodeling as it pertains to collagen deposition, hamsters received a single dose of radiation (40 Gy) specifically to the left everted cheek pouch on day 0 and were killed 16 or 28 days later.
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Intravascular stents are small tube-like structures expanded into stenotic arteries to restore blood flow perfusion to the downstream tissues.
A prevailed view of development biology holds that the commitment of primitive multi-potent cells to specific lineages is mediated by key transcription factors that activate downstream tissue-specific genes [32].
The ultra-short lifetime of ROS confines their activity to the illuminated volume, sparing downstream tissues from their toxicity.
Regional phase heterogeneity within the SCN may provide specifically phased output signals to different downstream tissues [13], [44] [46]; however, the regions shown here to adopt different phases may communicate similar information to the same target tissue.
Redundant signaling may augment the robustness and resilience of the system since the wider peak phase at the population level could increase the likelihood that downstream tissues will respond to output signals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com