Sentence examples for downstream terminal from inspiring English sources
No downstream terminal differentiation genes have been identified for the DVC transcription factor network defined here.
It is generally recognized that PPARγ and C/EBPα activate the downstream terminal adipocyte differentiation marker genes of aP2 [ 34].
The low levels of the potent anaphyatoxin C5a observed in our study most likely inhibit the downstream terminal complement pathway.
C3 lies at the heart of the complement network, as all three major activation pathways may result in cleavage of C3 and initiation of the downstream terminal pathway.
They show a striking conservation of sex-specific regulation, based on alternative splicing, and of the encoded sex-specific proteins, which are transcriptional regulators of downstream terminal genes that influence sexual differentiation of cells, tissues and organs.
Target genes encode a variety of proteins, including downstream terminal effectors such as proteins controlling the cell cycle or cell migration, transcription factors that presumably activate additional indirect target genes, and secreted molecules that may mediate further nonautonomous signaling events.
Genes at the downstream terminals, which are known as differentiation gene batteries, have been suggested to represent genes expressed in a cell that fulfill a specific function [ 23, 41].
Activation of C3 in turn activates the downstream common terminal pathway.
The MRFs subsequently interact with the MEF2 transcription factors that, although lacking intrinsic myogenic activity, cooperate with the MRFs to synergistically activate muscle-specific genes and the downstream myogenic terminal differentiation program (Molkentin and Olson 1996; Potthoff and Olson 2007).
For new and published spidroin N-terminal sequences, we associated each with its corresponding downstream C-terminal sequence.
In our case, the wild type sequence of the 20 amino-acid region unique to the N-terminus of Cav1.4wt contains six proline residues, while that of Cav1.4nob2 only contains one; furthermore, at the boundary of this region with the downstream N-terminal sequence, the wild type clone has a PGPP motif (recall PTPP motif for Kv4.2), while the Cav1.4nob2 construct has an NRPP motif.
