Sentence examples for downstream suppression from inspiring English sources
Overall the data for this pathway suggests an anti-apoptotic environment in the FGT due to downstream suppression of this pathway and not as a result of a decrease in apoptosis-inducing cytokines.
These results have been attributed to the blockade of IL 33 actions with downstream suppression of NF-kB activation [ 18].
As a first step toward establishing the feasibility of this model, we hypothesized that ligation of NKG2A receptors on activated TH2 cells would be expected to lead to downstream suppression of interleukin (IL -4 expressIL -423].
Further work in breast cancer cells demonstrated that metformin does not act as an "insulin-sensitizing" drug, but as a growth inhibitor; growth inhibition was mediated by upregulation of AMP-activated protein kinase (AMPK) activity and downstream suppression of signaling through the mammalian target of rapamycin (13, 14).
Endogenous inhibitory molecules appear in a hub, and disseminate their signals downstream through suppression of several activator molecules rather than directly networking.
It is clear from the findings of laboratories headed by Filipowicz, Steitz and other investigators, that RBPs and miRNAs are involved in intricate associations to affect downstream translational suppression or activation of target mRNAs to help meet cellular needs [ 65, 66].
First, metformin may directly activate adenosine monophosphate kinase (AMPK), resulting in the downstream inhibition of mTOR signaling and the consequent suppression of cell proliferation [ 5- 7].
Our studies revealed that while KCs are well equipped to respond to viral pathogens, latent infection with HPV results in suppression downstream of the PRRs as reflected by lower expression levels of effector molecules involved in innate and adaptive immune response.
Instead, most are downstream effects of suppression of VEGF signalling in endothelial cells of normal organs.
These effects are typically downstream consequences of suppression of cellular signalling pathways important in the regulation and maintenance of the microvasculature.
In this study, we have identified S100A2 as an integral component of BRCA1 tumour suppression downstream of the BRCA1 ΔNp63 transcription complex.
