Sentence examples for downstream substrates from inspiring English sources

IGF-1-induced receptor activation results in autophosphorylation of cytoplasmic kinase domains and enhances their capability to phosphorylate downstream substrates.

The activation of AMPK by GD was functional, as demonstrated by appropriate phosphorylation changes of mTOR and mTOR downstream substrates.

AMPK can directly phosphorylate multiple downstream substrates to inhibit ATP-consuming biosynthetic pathways and promote catabolic ATP regenerating processes to restore intracellular energy levels.

The Janus kinases (JAKs) are a family of intracellular non-receptor tyrosine kinases which transmit signals by phosphorylation of downstream substrates.

However, this does not rule out the possibility that allelic variants in direct regulators or downstream substrates of SIRT1 could play critical roles in extending lifespan in humans.

Kinases directly interact with and phosphorylate downstream substrates, thus modulating their functions.

Downstream substrates known to be regulated by Akt were also examined to determine isoform-specific pathways.

Activation of cdc2 allows the phosphorylation of downstream substrates required for mitosis [19].

ATM is activated after recruitment to DSBs and phosphorylates downstream substrates, initiating the signal transduction process [26].

To date, there has not been a systematic analysis of the downstream substrates of such receptor-activated SFKs.

In this study, we further demonstrate that ER stress modulates AKT downstream substrates specificity in a severity-dependent manner.