Sentence examples for downstream sense from inspiring English sources
Under this scenario, two sense genes are orientated in tandem, and a bidirectional promoter simultaneously drives the expression of the upstream antisense transcripts and the downstream sense gene.
A molecular mechanism has been established [80], [113], [114] for the observed abundant downstream sense strand tiling array signal of miRNA target genes in which 3' exonuclease degradation of the upstream cleavage product by EXORIBONUCLEASE4 (XRN4) is postulated.
It is apparent that the ancient MIRNA genes have a 'ping-pong-like' expression topology (downstream sense, upstream antisense; Figure 2A, arrows) similar to that previously described for miRNA target mRNAs [14].
Genome-wide analysis of tandem gene pairs showed that the level of antisense RNAs does not correlate with their own sense transcripts but rather with the downstream sense genes (p<5.36E-07; Pearson correlation), suggesting that bidirectional promoters might be involved in antisense transcription in at least a subset of tandem gene loci.
Our results indicated that distributions of PACs are closer to the upstream or downstream sense genes.
Finally, ChIP analyses showed more Tyr1-P on these upstream genes than on the corresponding downstream sense genes.
An ac current perturbation is applied at an upstream working electrode and the resulting ac potential response at a downstream sensing electrode is measured.
Components of calcium wave propagation (CWP, the proposed downstream sensing pathway) were also expressed in tissues with abundant TRPV1 expression, the muscle and epimysium layers.
Last, the components of proposed downstream sensing pathway were tested with western blotting to determine if they were expressed in tissues with positive mechanosensitive channel expression.
We found a significant excess of positive correlations between the expression of transcripts represented by novel contig clusters and the expression of nearby protein-coding genes for the upstream-sense, downstream-sense and upstream-antisense categories.
Novel transcripts located outside of annotated gene regions were classified into four categories, based on their location with respect to the nearest annotated gene: upstream-sense, downstream-sense, upstream-antisense and downstream-antisense.
