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Gazprom is expected to name an American partner for the Shtokman project soon; in return, it will want a "downstream" role in America, of just the sort that has been worrying the Europeans.
This poses an issue when trying to ascertain the downstream role of this immunomodulatory peptide.
Thus, Bim does not appear to play a downstream role in promoting death of Mcl-1-deficient thymocytes.
Enhanced Dvl2 level did not significantly interfere with stress mediated phosphorylation of eIF2α (Fig. 3A), suggesting a downstream role for Dvl2 for impairment of SG assembly.
In contrast, Bax has a more downstream role in effecting apoptosis, which perhaps explains its more predictable cytotoxicity on tumor cells [ 126*].
It should be pointed out that NAC had a minimal effect on mitochondrial morphology, thus suggesting a downstream role for ROS in Os-induced cell death.
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This latter observation suggests that they may also have downstream roles that affect encystment.
These genes gradually increase after the peak of rx3 expression, indicative of more downstream roles of Rx3 regulation.
That is, these models cannot distinguish between different downstream roles played by the same component activated in different contexts.
The role for DUBs proposed here in controlling the generation of a degradation signal is worth distinguishing from downstream roles for DUBs.
Oxidative stress and ROS generation are integral part of ER stress, which have both upstream and downstream roles in the UPR pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com