Based on this review of the literature, the future research directions for at-a-station relations relate to improving their applicability to the practical problems for which they are commonly used, whereas those for downstream relations relate to improving our ability to model downstream hydraulic geometry and incorporating those relations in models of landscape evolution.
This application requires that the downstream relations associated with lymphatic system components must only be to other lymphatic chains or vessels, must be at the appropriate level of granularity, and that every path through the lymphatic system must terminate at one of the two well known trunks of the lymphatic system.
Empirical studies of downstream relations have demonstrated that bankfull channel width generally increases at a rate slightly higher than suggested by Froude scaling, whereas channel depth typically increases at close to the rate associated with Froude scaling, but there are notable exceptions.
We tried to include downstream targets in our analysis and identified downstream targets for the 12 TFs using direct downstream relations known by the Ingenuity Pathway Knowledge Base (IPKB).
The terms 'upstream' and 'downstream' are also relative, for example the transition zone is downstream in relation to the headwaters but upstream in relation to the flood plains.
Altogether, these results suggest that the pattern of nucleotide variation along the insulin pathway is driven by gene expression level rather than by pleiotropic constraints or increased purifying selection in the downstream elements in relation to their function in mediating the cellular response.
Hydraulic geometry is of two types, at-a-station and downstream, and encompasses relations of channel width, depth, velocity, roughness, and slope each with discharge (Wolman 1955).
A similar entropy-based criterion was used by Szczurek et al. (2009) to learn regulatory relations downstream to a given signaling pathway.
With proven effectiveness, this research could offer an interesting starting point for the analysis of differences between watersheds, and to improve knowledge about downstream channel adjustment in relation, for example, to scale and landscape forcing (e.g. sediment transport, tectonics, lithology, climate, geomorphology, and anthropic pressure).
We analyzed BRCA1-IRIS downstream signaling pathways in relation to paclitaxel treatment.
