Sentence examples for downstream regulations from inspiring English sources

However, their states are determined regardless of other elements once the state of Mevalonic acid is given, thus such later downstream regulations are not as specific to the presence of statins.

It was therefore of interest to find gene categories performing specific meiotic functions that lie further downstream (regulation of meiotic transcription, meiosis I and meiotic chromosome segregation) among the up-regulated genes.

Moreover, the molecular mechanisms of upstream and downstream regulation of Slug are largely unknown.

ADARB1 encodes an RNA editing enzyme, expressed mainly in the central nervous system (CNS), which is involved in the downstream regulation of neurotransmitters [22].

In addition, cells are dynamic systems with complex regulatory networks that activate cascades of downstream regulation that is sensitive to type and frequency of incoming stimulus.

Regulated genes were associated with biological functions using previously published literature reports and various databases, in addition to upstream and downstream regulation analysis and canonical pathway analysis generated by Ingenuity Pathway Analysis (IPA) software.

The assays also suggested that compound 24 is an Hsp90 inhibitor, and that the Akt/mTOR pathway might be involved in the downstream regulation that leads to its antiproliferative activity.

These findings suggest that alternative models for hormonal control of avian clutch size need to be considered, perhaps involving downstream regulation of plasma PRL at the level of the ovary, or other hormones that have not been considered to date.

Although the biological function of CAR relies predominantly on chemical-mediated activation/deactivation through direct or indirect mechanisms, the expression level of CAR in response to endogenous signals or xenobiotic chemicals may also influence the downstream regulation of its target genes.

Since IL-6 overexpression contributes to the tumorigenic potency of basal cell carcinoma (BCC), this study was designed to investigate whether arecoline altered IL-6 expression and its downstream regulation of apoptosis and the cell cycle in cultured BCC-1/KMC cells.

TBR1 is involved in the downstream regulation of Sox5.