Sentence examples for downstream player from inspiring English sources

We find that the AbdB-Boss/Sev cascade affects integrin independent of Talin, while genetic interactions depict integrin as the central downstream player in this system.

An important downstream player in the effects of metabolic flexibility is the mitochondrion.

To accomplish this, we inhibited non-muscle myosin II, which is a downstream player in the Rho/ROCK pathway and an important component of stress fiber formation.

Through the ability to better parse and make use of this data, the idea is that these downstream players can then facilitate significant improvements in patient care, treatment and, really, basic understanding of how the body works via insights at the molecular level.

Taken together, these studies suggest that the Twist1 family might be the key downstream players in heart hypertrophy/dilation induced by abnormal Akt signaling (enhancement or reduction).

The differential analysis of multiprotein complexes containing variants of PrPC that are permissive or refractory to cleavage may lead the identification of the relevant sheddases and possibly also of downstream players involved in prion toxicity.

To analyze downstream players of EGFR-dependent refinement we first focused on the canonical EGFR pathway.

It was well established that the RANKL/RANK/OPG pathway can activate NF-κB and its downstream players [ 42].

Moreover, BIRC2/3-driven carcinogenesis may be mediated by downstream players other than NIK, given that NIK depletion did not completely abrogate BIRC2/3-induced malignant transformation.

31 In addition, a growing list of p53 target miRNAs and their target mRNAs have been identified as newly downstream players of the p53 pathway.

Although recent attempts to target key players in the TNFα signaling pathway have proven ineffective [ 6- 10], several studies have indicated that downstream players could represent better targets to combat muscle wasting.