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Development is particularly vulnerable to opposing trepidations, with multiple downstream outcomes, and this is why phenotypic plasticity is directly linked to development5.
Studies that evaluate the linkages between watershed improvement through Best Management Practices (BMPs) and downstream outcomes are few.
Measuring downstream outcomes such as the overall rates of FH diagnosis, cascade screening, ASCVD events or survival would require longitudinal observation after implementation of this algorithm and was not addressed in this study.
We also revealed two important downstream outcomes: whereas the lower strain judgments associated with a stress-is-enhancing mindset led to a higher estimate of the target's promotability, they also led to a lower likelihood of helping him.
This egalitarian approach to diminishing researcher views may have also meant down-grading, and eventually eliminating, researchers' focus on predictive models and downstream outcomes.
The effect of treatment choice on downstream outcomes such as recurrence and risk of death is not well understood.
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Studies suggest that early ventilator settings influence downstream outcome of critically ill patients [34].
Instead, we were concerned with the downstream outcome of chemotherapy treatment that could concurrently inhibit HIF- α and activate the p53 pathway.
Biochemically, the signaling state of a protein can be examined in the absence of such reagents directly by antibody immunoprecipitation of the protein followed by an in vitro kinase assay with substrate and radioactively labeled ATP or indirectly by transfection with a reporter construct that measures a downstream outcome of kinase activation such as ERK activation of AP-1.
In addition, we conducted a sensitivity analysis to examine the effect of including antihypertensive medication use in our regression models because of concern about adjusting for a potential downstream consequence of the BP outcome.
Furthermore, our trial was not sufficiently long or large to determine the effect of our interventions on downstream cardiovascular outcomes.
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