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"If you are not working on a target that is validated, then everything you do downstream of that could be a waste of time".
Immediately downstream of that constriction, no evidence exists for any overbank sedimentation during that same period.
The first was a depth filter that removed particulates and also bound DNA and endotoxin due to its charged nature, and the second downstream of that was a 0.65 µm filter that would prevent any possible additional cell debris from entering the patient.
The trouble isn't implementing it but the changes that have to be made downstream of that implementation.
You are no longer automating a specific task and constraining the inputs and outputs – since this new era of automation is flexible and can adapt with you, you now need to actively evaluate and manage both upstream and downstream of that automated process as well.
Downstream of that dam, the river gathers further urban runoff before finally making it into the Pacific.
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These results suggest that Tfcp2l1 exerts a unique function downstream of Stat3 that is necessary for a full self-renewal response to LIF.
Recently, Custodio and Feliu indicated that, in addition to KRAS, there are signaling events/molecules downstream of EGFR that can become unregulated [ 13].
Therefore, it is tempting to postulate that in this instance, Cdc42 mediates one of multiple signalling pathways downstream of Rac1, that when inactivated, partially disrupts VEGF secretion.
We are currently investigating the regulatory network downstream of Tbx3 that may contribute to increased endothelial cell affinity.
To identify mechanisms downstream of MEK5/ERK5 that might contribute to stem-like cell maintenance in colon cancer, we performed a comparative PCR array analysis of genes associated with CSC features in HCT116 tumorspheres treated with XMD8-92 or vehicle control.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com