Sentence examples for downstream module from inspiring English sources

We show that the noise in the output signal of the network can be affected significantly when the output is connected to a downstream module.

This construct, termed (N3 Mod2 + TE, was co-incubated with a complementary, donor form of the same module, (N5 Mod2(C2), as well as with a mutant of (N5 Mod2(C2) with an inactive ketosynthase domain, in order to determine the extent of intermediate channeling versus substrate diffusion into the downstream module.

As proof of concept, we constructed an l-Trp biosensor and used it to optimize the deoxyviolacein biosynthetic pathway, which we divided into two modules with l-Trp being the product of the upstream and the substrate of the downstream module for deoxyviolacein synthesis.

Thereafter, we examined whether Erk1/2 is the downstream module of RhoA/ROCK1 signalling during apoptosis regulation.

Another form of genome-scale validation is to examine if siRNA-mediated knockdowns of predicted upstream genes in a module result in altered expression of downstream module genes.

When the module is in the KS state, the ACP-bound polyketide chain is also accessible to the individual ketoreductase, dehydratase, and/or enoylreductase domains as well as to the ketosynthase domain of the downstream module.

In contrast, the lack of network redundancy and the lack of reservoirs of important compounds acting on various parts of downstream signaling modules results in greater network fragility for those downstream modules.

Overall, we show that iterative modules are remarkably adaptable while downstream modules are gatekeepers that select for correct polyketide chain length.

In the future, this platform can be readily used for engineering the downstream modules toward the production of important plant-sourced aromatic secondary metabolites.

This filtering procedure gave rise to separate networks for the main modules in the landscape which could then be used to more objectively identify the 'target' genes for the downstream module-to-regulator analysis.

This restart functionality is useful for debugging and troubleshooting complex workflow protocols and saves time by avoiding execution of downstream modules.