Sentence examples for downstream modifications of from inspiring English sources

NMDA receptor activation is followed by downstream modifications of intracellular signaling, including activation of nitric oxide synthase (NOS), which catalyzes the formation of nitric oxide from arginine.

Other reasons for the lack of associations between some of the type 2 diabetes CpG-SNPs and the analysed phenotypes could be that some of the type 2 diabetes CpG-SNPs do not affect gene expression or hormone secretion but possibly cause downstream modifications of mRNA or protein translation, or other phenotypes such as genome stability and recombination.

Based on this observation we hypothesize that stress may have a direct effect on NMDARs, which then leads to downstream modification of AMPARs phosphorylation.

We have described the characterization of a downstream modification of the novel TRAIL-based drug platform TR3 which has many highly desirable anticancer properties.

Consequently, the NRG pathway was evaluated by measuring ERK phosphorylation, a known downstream modification of NRG signaling (Won et al., 1999).

Furthermore, 4OHI3M is up-regulated in response to fungal attack and a downstream modification of this compound confers broad spectrum antifungal defense for A. thaliana (Bednarek et al. 2009).

The extent and specific types of differences in expression of intracellular and secreted proteins, in components of the various signaling pathways, and in downstream modification of target proteins, are compatible with the hypothesis of aberrant bladder urothelial cell differentiation in this illness.

In addition to abnormal expression of those gene products mentioned above, abnormal expression in BPS/IC bladder cells also appears to extend to the production of various cell signaling molecules and signaling receptors, as well as ultimate downstream modification of certain target proteins/enzymes.

Although the precise mechanism of action of Wld s remains controversial, several in vivo and in vitro genomic and proteomic studies have identified downstream modifications in the expression of genes and proteins (focused around cell-cycle status, cell stress and mitochondrial stability) that are robust indicators of modified axonal and synaptic vulnerability (29– 31).

In these cases, the selective incorporation of histone variants could be a molecular platform for downstream modifications and chromatin remodeling to acquire differentiation potential.

Furthermore, a wide range of modified protein variants (e.g. post-translational or other downstream modifications) might remain undetected by IHC.