Many downstream modification events in the life of polypeptide chains (involving longer nascent peptides) are also co-translational (Fig. 1C).
Last, it could be the result of low molecular weight of HA having more adverse effects, resulting in changes in the downstream signaling modification in the disease process, as discussed and reviewed elsewhere [ 35, 52, 54– 54].
We find four Ensembl genes with significantly more H3K4me2 modifications downstream in the gene.
MeCP2 is also required for expression of EZH2 and H3K27me3 modifications in the downstream coding region of the gene that impede transcriptional elongation.
This observation suggests that the common molecular mechanism remains in the upstream process of the developmental cascade, but also that secondary modifications in the downstream process generate a considerable difference in eyespot formation in each wing cell.
In these cases, the selective incorporation of histone variants could be a molecular platform for downstream modifications and chromatin remodeling to acquire differentiation potential.
The extent and specific types of differences in expression of intracellular and secreted proteins, in components of the various signaling pathways, and in downstream modification of target proteins, are compatible with the hypothesis of aberrant bladder urothelial cell differentiation in this illness.
Further, although many transgenic mouse lines with modifications in the Wnt signaling pathway exist, most harbor perturbations in downstream effectors, such as Apc or β-catenin.
In contrast, expression of the downstream genes was significantly down-regulated (gbs0560) or up-regulated (gbs1212) (p < 0.01) in conditions of acid stress revealing modifications in the efficiency of transcription termination directed by the two riboswitches.
The diverse modifications in the analysed spheroid body's genome fragment are not equally distributed over the whole sequence but accumulate downstream of the conserved nif gene region.
