Sentence examples for downstream modifications from inspiring English sources

Furthermore, a wide range of modified protein variants (e.g. post-translational or other downstream modifications) might remain undetected by IHC.

In these cases, the selective incorporation of histone variants could be a molecular platform for downstream modifications and chromatin remodeling to acquire differentiation potential.

NMDA receptor activation is followed by downstream modifications of intracellular signaling, including activation of nitric oxide synthase (NOS), which catalyzes the formation of nitric oxide from arginine.

Upon downstream modifications by cyclooxygenases, these precursors are modified to active compounds called eicosanoids (prostaglandins and leukotrienes), which may signal as lipid secondary messengers and promote differentiation (Wang & Dubois, 2010).

Other reasons for the lack of associations between some of the type 2 diabetes CpG-SNPs and the analysed phenotypes could be that some of the type 2 diabetes CpG-SNPs do not affect gene expression or hormone secretion but possibly cause downstream modifications of mRNA or protein translation, or other phenotypes such as genome stability and recombination.

Although the precise mechanism of action of Wld s remains controversial, several in vivo and in vitro genomic and proteomic studies have identified downstream modifications in the expression of genes and proteins (focused around cell-cycle status, cell stress and mitochondrial stability) that are robust indicators of modified axonal and synaptic vulnerability (29– 31).

Based on this observation we hypothesize that stress may have a direct effect on NMDARs, which then leads to downstream modification of AMPARs phosphorylation.

Many downstream modification events in the life of polypeptide chains (involving longer nascent peptides) are also co-translational (Fig. 1C).

Consequently, the NRG pathway was evaluated by measuring ERK phosphorylation, a known downstream modification of NRG signaling (Won et al., 1999).

We have described the characterization of a downstream modification of the novel TRAIL-based drug platform TR3 which has many highly desirable anticancer properties.

Furthermore, 4OHI3M is up-regulated in response to fungal attack and a downstream modification of this compound confers broad spectrum antifungal defense for A. thaliana (Bednarek et al. 2009).