Sentence examples for downstream modification from inspiring English sources
The phrase "downstream modification" is correct and usable in written English.
It can be used in contexts related to processes, particularly in fields like biology, engineering, or data processing, where changes occur later in a sequence or system. Example: "The downstream modification of proteins is crucial for their proper function and activity within the cell."
Based on this observation we hypothesize that stress may have a direct effect on NMDARs, which then leads to downstream modification of AMPARs phosphorylation.
Many downstream modification events in the life of polypeptide chains (involving longer nascent peptides) are also co-translational (Fig. 1C).
Consequently, the NRG pathway was evaluated by measuring ERK phosphorylation, a known downstream modification of NRG signaling (Won et al., 1999).
We have described the characterization of a downstream modification of the novel TRAIL-based drug platform TR3 which has many highly desirable anticancer properties.
Furthermore, 4OHI3M is up-regulated in response to fungal attack and a downstream modification of this compound confers broad spectrum antifungal defense for A. thaliana (Bednarek et al. 2009).
In addition to abnormal expression of those gene products mentioned above, abnormal expression in BPS/IC bladder cells also appears to extend to the production of various cell signaling molecules and signaling receptors, as well as ultimate downstream modification of certain target proteins/enzymes.
In these cases, the selective incorporation of histone variants could be a molecular platform for downstream modifications and chromatin remodeling to acquire differentiation potential.
NMDA receptor activation is followed by downstream modifications of intracellular signaling, including activation of nitric oxide synthase (NOS), which catalyzes the formation of nitric oxide from arginine.
Furthermore, a wide range of modified protein variants (e.g. post-translational or other downstream modifications) might remain undetected by IHC.
Upon downstream modifications by cyclooxygenases, these precursors are modified to active compounds called eicosanoids (prostaglandins and leukotrienes), which may signal as lipid secondary messengers and promote differentiation (Wang & Dubois, 2010).
Although the precise mechanism of action of Wld s remains controversial, several in vivo and in vitro genomic and proteomic studies have identified downstream modifications in the expression of genes and proteins (focused around cell-cycle status, cell stress and mitochondrial stability) that are robust indicators of modified axonal and synaptic vulnerability (29– 31).
