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CO production is greatest in regions which undergo significant downstream interaction.
Therefore, we propose the existence of as yet unknown downstream interaction partners for NLRP proteins.
One bait vector containing the 5' unique site combined with the SH3 domain (611 bp fragment) of SmTK3 was constructed to screen for "downstream" interaction partners [13].
Compared to the network from untreated patients, Jagged1 therapy induced an increase in the interaction weight between JAG1-TNF and the downstream interaction TNF-IFNG, as well as a decrease in the interaction weight between CD28-TNF (Figure 4A).
Yet another possible explanation for the few observed NLRP downstream interaction partners, may be provided by recently observed heterotypic interactions among NACHT-domains of NLRC4 and other NLR proteins (NOD1, NOD2, NLRP1) [28].
Further work will need to be carried out to determine the downstream interaction of the TaAgl10 protein.
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Downstream interactions, which correspond to the proximity of flames from their burned gas side, are the dominant contribution to flame flame interactions.
Importance of chain carrier radicals such as H is also addressed in the downstream interactions between lean premixed (50% H2 + 50% CO)–air and CH4 air flames.
Downstream interactions between lean premixed flames with mutually different fuels of (50% H2 + 50% CO) and CH4 are numerically investigated particularly on and near lean extinction limits in order to provide fundamental database for the design of cofiring burners with hydrocarbon and syngas under a retrofit concept.
In both cases, only a small number of genes had direct downstream interactions.
The existence of such downstream interactions has been suggested by several previous studies.
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